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Mariners at Astros Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 22

Its Thursday, May 22 and the Mariners (28-20) are in Houston to take on the Astros (25-24). George Kirby is slated to take the mound for Seattle against Lance McCullers for Houston.

The Astros are hoping to bounce back from an 8-4 loss and a dropped series against the Tampa Bay Rays when McCullers takes the mound today. Hunter Brown didn’t have his best stuff yesterday. He gave up five earned runs from seven hits in 5.0 innings.

The AL West-leading Mariners look to build off their 6-5 win against the Chicago White Sox.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Mariners at Astros

Date: Thursday, May 22, 2025
Time: 8:10PM EST
Site: Minute Maid Park
City: Houston, TX
Network/Streaming: Space City Home Network, ROOTNW

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Mariners at the Astros

The latest odds as of Thursday:

Moneyline: Mariners (-134), Astros (+114)
Spread: Mariners -1.5
Total: 8.0 runs

Probable starting pitchers for Mariners at Astros

Pitching matchup for May 22, 2025: George Kirby vs. Lance McCullers
- Mariners: George Kirby
- Astros: Lance McCullers, (0-1, 7.88 ERA)
  Last outing (Texas Rangers, 5/16): 4.0 Innings Pitched, 0 Earned Runs Allowed, 4 Hits Allowed, 1 Walks, and 2 Strikeouts

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Top betting trends & insights to know ahead of Mariners at Astros

The Mariners have won 4 of their last 5 games against teams with winning records
The Under has cashed in 4 of the Astros’ last 5 games with Lance McCullers starting
The Mariners have covered the Run Line in 5 straight games at the Astros

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Mariners and the Astros

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Thursday’s game between the Mariners and the Astros:

Moneyline: NBC Sports Bet is recommending a play on the Seattle Mariners on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Houston Astros at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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