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Mariners at Red Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for April 22

Its Tuesday, April 22 and the Mariners (12-10) are in Boston to take on the Red Sox (13-11).

Bryce Miller is slated to take the mound for Seattle against Brayan Bello for Boston.

Seattle was off yesterday. They enter the series having won two straight and four of their last five. The Red Sox knocked off the White Sox on Patriots Day, 4-2. Walker Buehler gave up one run over seven innings to pick up his third win of the season and Kristian Campbell drove in a couple runs to spark the offense.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Mariners at Red Sox

Date: Tuesday, April 22, 2025
Time: 6:45PM EST
Site: Fenway Park
City: Boston, MA
Network/Streaming: RSNW, NESN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Mariners at the Red Sox

The latest odds as of Tuesday:

Moneyline: Mariners (+115), Red Sox (-135)
Spread: Red Sox -1.5
Total: 9.0 runs

Probable starting pitchers for Mariners at Red Sox

Pitching matchup for April 22, 2025: Bryce Miller vs. Brayan Bello
- Mariners: Bryce Miller (1-2, 3.43 ERA)
  Last outing: 4/16 at Cincinnati - 5IP, 0ER, 3H, 2BB, 8K
- Red Sox: Brayan Bello
  Last outing: This is his first start of the 2025 season

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Top betting trends & insights to know ahead of Mariners at Red Sox

The Mariners have won 4 of their last 5 games on the road
The Under is 12-7-1 in the Red Sox’s games against American League teams this season
The Mariners have covered the Run Line the last three times they have enjoyed a rest advantage vs. their opponent

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Mariners and the Red Sox

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Mariners and the Red Sox:

Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Seattle Mariners at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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