, /PRNewswire/ -- In a stunning revelation that will reshape the conversation around Elizabeth Holmes and her work at Theranos, one of the largest Specialty Labs in the Nation has confirmed that Holmes' diagnostic technology was in fact Accurate—and that her suppressed Test Result findings regarding Avastin®, a cancer drug were very accurate during the 15 month Pfizer study in 2007.

In 2007 and 2008, Holmes conducted a study for Pfizer investigating the angiogenesis process and the effect of Bevacizumab, an anti-VEGF antibody therapy used in cancer treatment under the brand name, Avastin® https://files.cand.uscourts.gov/files/18-CR-258%20USA%20v.%20Holmes/Trial%20Exh.%200143/Trial%20Exh.%200143%20Email.pdf

See page 0012 of Trial exhibit 0143. – bottom half of 0012 shows the Avastin® affect.

The Pfizer contract with Theranos was executed on December 12th 2006  worth $900,000.00. https://files.cand.uscourts.gov/files/18-CR-258%20USA%20v.%20Holmes/Trial%20Exh.%2014112/Trial%20Exh.%2014112%20Agreement.pdf

The study took place in clinics and in patient homes with her machine wirelessly transmitting Results to Theranos servers and the Pfizer portal during the course.

Her research demonstrated that while the drug initially appeared to suppress VEGF levels, that was only true using another companies reagent that is used by LabCorp and many labs across the nation called, R&D Systems VEGF ELISA. Avastin® is a monoclonal antibody that attaches to VEGF in the body to prevent the body from making blood vessels (angiogenesis) so the cancer will not spread. The problem is, ELISA testing using Antibodies, in fact the same antibody as Avastin, Anti-VEGF or better known as Bevacizumab. This causes a problem when testing for VEGF because you cannot detect it due to the same antibody being present. It doesn't know VEGF is present, it is being blocked by Anti-VEGF.

She also discovered that Avastin causes what's called a VEGF complex, which means the body starts creating TONS of VEGF. VEGF levels spiked dramatically—showing an alarming surge from an average of 140 pg/mL to over 8,000 pg/mL. This post-treatment VEGF REBOUND effect signals a rapid increase in blood vessel formation, which could exacerbate cancer proliferation rather than control it. Her study was also confirmed independently in 2023 by JAMA open network. https://www.cancertherapyadvisor.com/news/discontinuation-of-bevacizumab-in-ovarian-cancer-may-result-in-rebound/

Despite Holmes' findings, Pfizer and Dr. Shane Weber who testified against Elizabeth Holmes in court, rejected the results on December 31st 2008. https://files.cand.uscourts.gov/files/18-CR-258%20USA%20v.%20Holmes/Trial%20Exh.%200167/Trial%20Exh.%200167%20Report.pdf

Holmes' research was originally conducted using the Theranos Edison (TSPU - Theranos System Processing Unit), which ran proprietary assays to measure both free and total VEGF levels. Unlike traditional laboratory methods—which only detect unbound VEGF—the Theranos approach provided a complete picture, revealing the dangers of VEGF suppression therapy when treatment is discontinued.

Holmes' Study was originally conducted using the Edison or aka the TSPU - Theranos Systems Processing Unit, which ran proprietary assays developed in house at Theranos and commercially available test kits used by Lab Giants, LabCorp and Quest. In this case of VEGF, she used her proprietary test measure both free and total VEGF levels. Unlike traditional laboratory methods—which only detect unbound VEGF—the Theranos approach provided a complete picture, revealing the dangers of VEGF suppression therapy when treatment is discontinued because she could detect the TOTAL VEGF.

Today, Access Medical Labs has demonstrated that:

  • Holmes' technology was indeed Accurate.
  • Conventional testing methods, such as those used by LabCorp may underreport the true impact of anti-VEGF drugs.
  • When Bevacizumab exits the bloodstream, a VEGF rebound may occur and CANNOT be detected early enough due to VEGF being blocked which could drastically increase the spread of cancer.
  • Our lab testing proves that Elizabeth Holmes did not lie. Her tests & machine worked.

Ryan ElHosseiny
Access Medical Labs
954-494-1664
www.accessmedlab.com

SOURCE Access Medical Labs

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